Genetic approaches for the identification of apoptotic components

Erina Kuranaga, Masayuki Miura

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Jun amino-terminal kinase (JNK) mediates a physiological stress signal that leads to cell death. However, the role of the JNK pathway in intrinsic cell death execution mechanisms is largely unknown. In a genetic screen for dominant suppressors of Reaper (Rpr)-induced cell death, we identified Drosophila chromosomal regions that contain genes which are homologous to apoptosis signal-regulating kinase (ASK1) and Drosophila tumor necrosis factor receptor-associated factor 1 (DTRAF1). We present evidence that the killer signal initiates the JNK pathway via proteasome-mediated degradation of Drosophila inhibitor of apoptosis protein 1 (DIAP1) to promote cell death.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalMedical Molecular Morphology
Volume38
Issue number1
DOIs
Publication statusPublished - 2005 Dec 1
Externally publishedYes

Keywords

  • Apoptosis
  • ASK1
  • Drosophila
  • IAPs
  • JNK
  • TRAFs

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology

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