Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia

Hiromitsu Shimizu, Yoshimi Iwayama, Kazuo Yamada, Tomoko Toyota, Yoshio Minabe, Kauhiko Nakamura, Mizuho Nakajima, Eiji Hattori, Norio Mori, Noriko Osumi, Takeo Yoshikawa

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Accumulating evidence suggests that the pathologic lesions of schizophrenia may in part be due to the altered cytoskeletal architecture of neurons. Microtubule-associated proteins (MAPs) that bind to cytoskeletal microtubules to stabilize their assembly are prominently expressed in neurons. Of the MAPs, MAP6 (STOP) has a particular relevance to schizophrenia pathology, since mice deficient in the gene display neuroleptic-responsive behavioral defects. Here we examined the genetic contribution of MAP6 to schizophrenia in a case (n = 570) -control (n = 570) study, using dense single nucleotide polymorphism (SNP) markers. We detected nominal allelic (p = 0.0291) and haplotypic (global p = 0.0343 for 2 SNP-window, global p = 0.0138 for 3 SNP-window) associations between the 3′ genomic interval of the gene and schizophrenia. MAP6 transcripts are expressed as two isoforms. A postmortem brain expression study showed up-regulation of mRNA isoform 2 in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia. These data suggest that the contribution of MAP6 to the processes that lead to schizophrenia should be further investigated.

Original languageEnglish
Pages (from-to)244-252
Number of pages9
JournalSchizophrenia Research
Volume84
Issue number2-3
DOIs
Publication statusPublished - 2006 Jun

Keywords

  • Cytoskeleton
  • Gene expression
  • Haplotype
  • Isoform
  • Microtubule-associated protein
  • Postmortem brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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