Abstract
The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.
Original language | English |
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Pages (from-to) | 582-589 |
Number of pages | 8 |
Journal | Japanese Journal of Neurosurgery |
Volume | 22 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2013 Aug 25 |
Keywords
- G-CIMP
- IDH1
- TCGA
ASJC Scopus subject areas
- Surgery
- Clinical Neurology