The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.
ASJC Scopus subject areas
- Clinical Neurology