Genetic alterations involving the progression of human gliomas

Yukihiko Sonoda; Teiji Tominaga

doi:10.7887/jcns.22.582

Genetic alterations involving the progression of human gliomas

Yukihiko Sonoda, Teiji Tominaga

MED - Medical Sciences

Research output: Contribution to journal › Article

Abstract

The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.

Original language	English
Pages (from-to)	582-589
Number of pages	8
Journal	Japanese Journal of Neurosurgery
Volume	22
Issue number	8
DOIs	https://doi.org/10.7887/jcns.22.582
Publication status	Published - 2013 Aug 25

Keywords

G-CIMP
IDH1
TCGA

ASJC Scopus subject areas

Surgery
Clinical Neurology

Access to Document

10.7887/jcns.22.582

Fingerprint Dive into the research topics of 'Genetic alterations involving the progression of human gliomas'. Together they form a unique fingerprint.

Cite this

Sonoda, Y., & Tominaga, T. (2013). Genetic alterations involving the progression of human gliomas. Japanese Journal of Neurosurgery, 22(8), 582-589. https://doi.org/10.7887/jcns.22.582

@article{f33eb721596e43d9806ffd6163dce037,

title = "Genetic alterations involving the progression of human gliomas",

abstract = "The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.",

keywords = "G-CIMP, IDH1, TCGA",

author = "Yukihiko Sonoda and Teiji Tominaga",

year = "2013",

month = aug,

day = "25",

doi = "10.7887/jcns.22.582",

language = "English",

volume = "22",

pages = "582--589",

journal = "Japanese Journal of Neurosurgery",

issn = "0917-950X",

publisher = "Japanese Congress of Neurological Surgeons",

number = "8",

}

TY - JOUR

T1 - Genetic alterations involving the progression of human gliomas

AU - Sonoda, Yukihiko

AU - Tominaga, Teiji

PY - 2013/8/25

Y1 - 2013/8/25

N2 - The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.

AB - The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.

KW - G-CIMP

KW - IDH1

KW - TCGA

UR - http://www.scopus.com/inward/record.url?scp=84925118791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925118791&partnerID=8YFLogxK

U2 - 10.7887/jcns.22.582

DO - 10.7887/jcns.22.582

M3 - Article

AN - SCOPUS:84925118791

VL - 22

SP - 582

EP - 589

JO - Japanese Journal of Neurosurgery

JF - Japanese Journal of Neurosurgery

SN - 0917-950X

IS - 8

ER -