Genetic alterations involving the progression of human gliomas

Yukihiko Sonoda; Teiji Tominaga

doi:10.7887/jcns.22.582

Genetic alterations involving the progression of human gliomas

Yukihiko Sonoda, Teiji Tominaga

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.

Original language	English
Pages (from-to)	582-589
Number of pages	8
Journal	Japanese Journal of Neurosurgery
Volume	22
Issue number	8
DOIs	https://doi.org/10.7887/jcns.22.582
Publication status	Published - 2013 Aug 25

Keywords

G-CIMP
IDH1
TCGA

ASJC Scopus subject areas

Surgery
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7887/jcns.22.582

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AB - The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.

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Genetic alterations involving the progression of human gliomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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