Genetic alterations involving the progression of human gliomas

Yukihiko Sonoda, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

Abstract

The Cancer Genome Atlas (TCGA) aims to catalogue and discover major cancer-causing genetic alterations in large cohorts of human tumors through integrated multi-dimensional analyses. The first cancer studied by the TCGA pilot project was glioblastoma. Here, we review four topics; 1) Frequent genetic alterations in three critical signaling pathways, 2) IDH1 gene, 3) Classification of GBM based on molecular profiling, and 4) Glioma CpG island methylator phenotype (G-CIMP) brought by the TCGA pilot study. These results confirmed the heterogeneity of GBM and may provide useful information for future molecular targeting therapies.

Original languageEnglish
Pages (from-to)582-589
Number of pages8
JournalJapanese Journal of Neurosurgery
Volume22
Issue number8
DOIs
Publication statusPublished - 2013 Aug 25

Keywords

  • G-CIMP
  • IDH1
  • TCGA

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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