Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

Yoko Honda, Akira Higashibata, Yohei Matsunaga, Yukiko Yonezawa, Tsuyoshi Kawano, Atsushi Higashitani, Kana Kuriyama, Toru Shimazu, Masashi Tanaka, Nathaniel J. Szewczyk, Noriaki Ishioka, Shuji Honda

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.

    Original languageEnglish
    Article number487
    JournalScientific reports
    Volume2
    DOIs
    Publication statusPublished - 2012

    ASJC Scopus subject areas

    • General

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