Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

Yoko Honda, Akira Higashibata, Yohei Matsunaga, Yukiko Yonezawa, Tsuyoshi Kawano, Atsushi Higashitani, Kana Kuriyama, Toru Shimazu, Masashi Tanaka, Nathaniel J. Szewczyk, Noriaki Ishioka, Shuji Honda

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.

Original languageEnglish
Article number487
JournalScientific reports
Volume2
DOIs
Publication statusPublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • General

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