Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

Yoko Honda; Akira Higashibata; Yohei Matsunaga; Yukiko Yonezawa; Tsuyoshi Kawano; Atsushi Higashitani; Kana Kuriyama; Toru Shimazu; Masashi Tanaka; Nathaniel J. Szewczyk; Noriaki Ishioka; Shuji Honda

doi:10.1038/srep00487

Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

Yoko Honda, Akira Higashibata, Yohei Matsunaga, Yukiko Yonezawa, Tsuyoshi Kawano, Atsushi Higashitani, Kana Kuriyama, Toru Shimazu, Masashi Tanaka, Nathaniel J. Szewczyk, Noriaki Ishioka, Shuji Honda

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.

Original language	English
Article number	487
Journal	Scientific reports
Volume	2
DOIs	https://doi.org/10.1038/srep00487
Publication status	Published - 2012

ASJC Scopus subject areas

General

Access to Document

10.1038/srep00487

Fingerprint Dive into the research topics of 'Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans'. Together they form a unique fingerprint.

Cite this

Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans. / Honda, Yoko; Higashibata, Akira; Matsunaga, Yohei; Yonezawa, Yukiko; Kawano, Tsuyoshi; Higashitani, Atsushi; Kuriyama, Kana; Shimazu, Toru; Tanaka, Masashi; Szewczyk, Nathaniel J.; Ishioka, Noriaki; Honda, Shuji.

In: Scientific reports, Vol. 2, 487, 2012.

Research output: Contribution to journal › Article › peer-review

@article{6c94386f2c6844e5a2a5078535caca3a,

title = "Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans",

abstract = "How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.",

author = "Yoko Honda and Akira Higashibata and Yohei Matsunaga and Yukiko Yonezawa and Tsuyoshi Kawano and Atsushi Higashitani and Kana Kuriyama and Toru Shimazu and Masashi Tanaka and Szewczyk, {Nathaniel J.} and Noriaki Ishioka and Shuji Honda",

year = "2012",

doi = "10.1038/srep00487",

language = "English",

volume = "2",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

AU - Honda, Yoko

AU - Higashibata, Akira

AU - Matsunaga, Yohei

AU - Yonezawa, Yukiko

AU - Kawano, Tsuyoshi

AU - Higashitani, Atsushi

AU - Kuriyama, Kana

AU - Shimazu, Toru

AU - Tanaka, Masashi

AU - Szewczyk, Nathaniel J.

AU - Ishioka, Noriaki

AU - Honda, Shuji

PY - 2012

Y1 - 2012

N2 - How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.

AB - How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.

UR - http://www.scopus.com/inward/record.url?scp=84863800657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863800657&partnerID=8YFLogxK

U2 - 10.1038/srep00487

DO - 10.1038/srep00487

M3 - Article

C2 - 22768380

AN - SCOPUS:84863800657

VL - 2

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 487

ER -