TY - JOUR
T1 - Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans
AU - Honda, Yoko
AU - Higashibata, Akira
AU - Matsunaga, Yohei
AU - Yonezawa, Yukiko
AU - Kawano, Tsuyoshi
AU - Higashitani, Atsushi
AU - Kuriyama, Kana
AU - Shimazu, Toru
AU - Tanaka, Masashi
AU - Szewczyk, Nathaniel J.
AU - Ishioka, Noriaki
AU - Honda, Shuji
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.
AB - How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.
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U2 - 10.1038/srep00487
DO - 10.1038/srep00487
M3 - Article
C2 - 22768380
AN - SCOPUS:84863800657
VL - 2
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 487
ER -