TY - JOUR
T1 - Genes and circuits of courtship behaviour in drosophila males
AU - Yamamoto, Daisuke
AU - Koganezawa, Masayuki
PY - 2013/10/1
Y1 - 2013/10/1
N2 - In Drosophila melanogaster, the causal links among a complex behaviour, single neurons and single genes can be demonstrated through experimental manipulations. A key player in establishing the male courtship circuitry is the fruitless (fru) gene, the expression of which yields the FruM proteins in a subset of male but not female neurons. FruM probably regulates chromatin states, leading to single-neuron sex differences and, consequently, a sexually dimorphic circuitry. The mutual connections among fru-expressing neurons-including primary sensory afferents, central interneurons such as the P1 neuron cluster that triggers courtship, and courtship motor pattern generators-probably form the core portion of the male courtship circuitry.
AB - In Drosophila melanogaster, the causal links among a complex behaviour, single neurons and single genes can be demonstrated through experimental manipulations. A key player in establishing the male courtship circuitry is the fruitless (fru) gene, the expression of which yields the FruM proteins in a subset of male but not female neurons. FruM probably regulates chromatin states, leading to single-neuron sex differences and, consequently, a sexually dimorphic circuitry. The mutual connections among fru-expressing neurons-including primary sensory afferents, central interneurons such as the P1 neuron cluster that triggers courtship, and courtship motor pattern generators-probably form the core portion of the male courtship circuitry.
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U2 - 10.1038/nrn3567
DO - 10.1038/nrn3567
M3 - Review article
C2 - 24052176
AN - SCOPUS:84884575862
VL - 14
SP - 681
EP - 692
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
SN - 1471-003X
IS - 10
ER -