TY - JOUR
T1 - Genes and circuits of courtship behaviour in drosophila males
AU - Yamamoto, Daisuke
AU - Koganezawa, Masayuki
N1 - Funding Information:
The authors’ work is funded by Grants-in-Aid for Scientific Research (24113502, 23220007, 1802012 to D.Y., and 24570082 and 23115702 to M.K.) from MEXT, the Strategic Japanese-French Cooperative Program from JST and a Life Science Grant from the Takeda Science Foundation. The authors thank H. Ito for preparing figure 2 and M. Suyama and S. Abe for secretarial assistance.
PY - 2013/10
Y1 - 2013/10
N2 - In Drosophila melanogaster, the causal links among a complex behaviour, single neurons and single genes can be demonstrated through experimental manipulations. A key player in establishing the male courtship circuitry is the fruitless (fru) gene, the expression of which yields the FruM proteins in a subset of male but not female neurons. FruM probably regulates chromatin states, leading to single-neuron sex differences and, consequently, a sexually dimorphic circuitry. The mutual connections among fru-expressing neurons-including primary sensory afferents, central interneurons such as the P1 neuron cluster that triggers courtship, and courtship motor pattern generators-probably form the core portion of the male courtship circuitry.
AB - In Drosophila melanogaster, the causal links among a complex behaviour, single neurons and single genes can be demonstrated through experimental manipulations. A key player in establishing the male courtship circuitry is the fruitless (fru) gene, the expression of which yields the FruM proteins in a subset of male but not female neurons. FruM probably regulates chromatin states, leading to single-neuron sex differences and, consequently, a sexually dimorphic circuitry. The mutual connections among fru-expressing neurons-including primary sensory afferents, central interneurons such as the P1 neuron cluster that triggers courtship, and courtship motor pattern generators-probably form the core portion of the male courtship circuitry.
UR - http://www.scopus.com/inward/record.url?scp=84884575862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884575862&partnerID=8YFLogxK
U2 - 10.1038/nrn3567
DO - 10.1038/nrn3567
M3 - Review article
C2 - 24052176
AN - SCOPUS:84884575862
VL - 14
SP - 681
EP - 692
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
SN - 1471-003X
IS - 10
ER -