Genes and circuits of courtship behaviour in drosophila males

Daisuke Yamamoto, Masayuki Koganezawa

    Research output: Contribution to journalReview articlepeer-review

    156 Citations (Scopus)

    Abstract

    In Drosophila melanogaster, the causal links among a complex behaviour, single neurons and single genes can be demonstrated through experimental manipulations. A key player in establishing the male courtship circuitry is the fruitless (fru) gene, the expression of which yields the FruM proteins in a subset of male but not female neurons. FruM probably regulates chromatin states, leading to single-neuron sex differences and, consequently, a sexually dimorphic circuitry. The mutual connections among fru-expressing neurons-including primary sensory afferents, central interneurons such as the P1 neuron cluster that triggers courtship, and courtship motor pattern generators-probably form the core portion of the male courtship circuitry.

    Original languageEnglish
    Pages (from-to)681-692
    Number of pages12
    JournalNature Reviews Neuroscience
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - 2013 Oct

    ASJC Scopus subject areas

    • Neuroscience(all)

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