Generation of signaling molecules by de novo sphingolipid synthesis

Kazuyuki Kitatani, L. Ashley Cowart, Yusuf A. Hannun

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Sphingolipids are abundant components of cellular membranes in eukaryotic cells as well as potent signaling molecules. De novo sphingolipid biosynthesis begins with condensation of L-serine and palmitoyl-CoA, generating sphingoid bases, ceramide, and other species through a series of reactions. Ceramide can also be formed from free sphingoid bases, which has been termed the' salvage' pathway. Sphingolipids from both the de novo and salvage pathways increase with exposure of yeast or mammals to various stimuli such as Fas ligands, chemotherapeutic drugs, tumor necrosis factor-γ and heat stress, and then act as lipid second messengers mediating inflammatory responses, senescence, cell cycle arrest, apoptosis or stress responses. Therefore, generation of signaling molecules by de novo synthesis and/or salvage accounts not only for homeostasis, but also for several disorders resulting from aberrant sphingolipid accumulation or depletion.

Original languageEnglish
Title of host publicationSphingolipid Biology
PublisherSpringer Japan
Pages153-165
Number of pages13
ISBN (Print)4431341986, 9784431341987
DOIs
Publication statusPublished - 2006 Dec 1

Keywords

  • ceramide
  • ceramide synthase
  • de novo sphingolipid synthesis
  • serine palmitoyltransferase
  • sphingoid bases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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