Generation of PGS/PCL blend nanofibrous scaffolds mimicking corneal stroma structure

Sahar Salehi, Mohammadhossein Fathi, Shaghayegh Haghjooy Javanmard, Thomas Bahners, Jochen S. Gutmann, Süleyman Ergün, Klaus P. Steuhl, Thomas A. Fuchsluger

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Abstract

    Morphological studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(-caprolactone)(PCL) blends for application as corneal tissue scaffolds are presented. Parallel conductive bars are used as ground electrode to generate unidirectional nanofibers. Scaffolds have fibers diameter in the range of 550-300nm. The structural stability and wettability, especially the in vitro degradation rate, of the electrospun scaffolds can be controlled by regulating the blended ratio of the polymers. The results indicate that PGS/PCL nanofiber scaffolds can be considered as ideal candidates for corneal tissue engineering scaffolds. The particular motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of the cornea. Morphological and degradation studies of aligned nanofibers scaffolds made of poly(glycerol sebacate)(PGS)/poly(-caprolactone)(PCL) blends for corneal tissue engineering are reported. Scaffolds have fibers diameter in the range of 550-300nm. The motivation for this work is to engineer a tissue-like construct that will mimic the stromal tissue of cornea.

    Original languageEnglish
    Pages (from-to)455-469
    Number of pages15
    JournalMacromolecular Materials and Engineering
    Volume299
    Issue number4
    DOIs
    Publication statusPublished - 2014 Apr

    Keywords

    • biodegradable
    • elastomers
    • electrospinning
    • oriented fibers
    • tissue engineering

    ASJC Scopus subject areas

    • Chemical Engineering(all)
    • Organic Chemistry
    • Polymers and Plastics
    • Materials Chemistry

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  • Cite this

    Salehi, S., Fathi, M., Javanmard, S. H., Bahners, T., Gutmann, J. S., Ergün, S., Steuhl, K. P., & Fuchsluger, T. A. (2014). Generation of PGS/PCL blend nanofibrous scaffolds mimicking corneal stroma structure. Macromolecular Materials and Engineering, 299(4), 455-469. https://doi.org/10.1002/mame.201300187