Generation of microgrooved silica nanotube membranes with sustained drug delivery and cell contact guidance ability by using a Teflon microfluidic chip

Song Chen, Xuetao Shi, Shanmugavel Chinnathambi, Hongkai Wu, Nobutaka Hanagata

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Silica nanotubes have been extensively applied in the biomedical field. However, very little attention has been paid to the fabrication and application of micropatterned silica nanotubes. In the present study, microgrooved silica nanotube membranes were fabricated in situ by microgrooving silica-coated collagen hybrid fibril hydrogels in a Teflon microfluidic chip followed by calcination for removal of collagen fibrils. Scanning electron microscopy images showed that the resulting silica nanotube membranes displayed a typical microgroove/ridge surface topography with ∼50 μm microgroove width and ∼120 μm ridge width. They supported adsorption of bone morphogenetic protein 2 (BMP-2) and exhibited a sustained release behavior for BMP-2. After culturing with osteoblast MC3T3-E1 cells, they induced an enhanced osteoblast differentiation due to the release of biologically active BMP-2 and a strong contact guidance ability to directly align and elongate osteoblasts due to the presence of microgrooved surface topography, indicating their potential application as a multi-functional cell-supporting matrix for tissue generation.

Original languageEnglish
Article number015005
JournalScience and Technology of Advanced Materials
Volume14
Issue number1
DOIs
Publication statusPublished - 2013 Feb
Externally publishedYes

Keywords

  • Teflon chip
  • cell alignment and elongation
  • drug delivery
  • microgroove
  • silica nanotube

ASJC Scopus subject areas

  • Materials Science(all)

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