Generation of HIV latency in humanized BLT mice

Paul W. Denton, Rikke Olesen, Shailesh K. Choudhary, Nancy M. Archin, Angela Wahl, Michael D. Swanson, Morgan Chateau, Tomonori Nochi, John F. Krisko, Rae Ann Spagnuolo, David M. Margolis, J. Victor Garcia

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice. We also demonstrate that antiretroviral therapy (ART)-treated humanized BLT mice harbor latently infected resting human CD4 + T cells that can be induced ex vivo to produce HIV. We observed that the levels of infected resting human CD4 + T cells present in BLT mice are within the range of those observed circulating in patients undergoing suppressive ART. These results demonstrate the potential of humanized BLT mice as an attractive model for testing the in vivo efficacy of novel HIV eradication strategies.

Original languageEnglish
Pages (from-to)630-634
Number of pages5
JournalJournal of virology
Volume86
Issue number1
DOIs
Publication statusPublished - 2012 Jan

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Denton, P. W., Olesen, R., Choudhary, S. K., Archin, N. M., Wahl, A., Swanson, M. D., Chateau, M., Nochi, T., Krisko, J. F., Spagnuolo, R. A., Margolis, D. M., & Victor Garcia, J. (2012). Generation of HIV latency in humanized BLT mice. Journal of virology, 86(1), 630-634. https://doi.org/10.1128/JVI.06120-11