TY - JOUR
T1 - Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex
AU - Kragel, Philip A.
AU - Kano, Michiko
AU - Van Oudenhove, Lukas
AU - Ly, Huynh Giao
AU - Dupont, Patrick
AU - Rubio, Amandine
AU - Delon-Martin, Chantal
AU - Bonaz, Bruno L.
AU - Manuck, Stephen B.
AU - Gianaros, Peter J.
AU - Ceko, Marta
AU - Reynolds Losin, Elizabeth A.
AU - Woo, Choong Wan
AU - Nichols, Thomas E.
AU - Wager, Tor D.
N1 - Funding Information:
We thank S. Fukudo, T. Muratsubaki and J. Morishita for assistance with data collection; K. Ochsner for sharing data from studies of negative emotion; T. Braver and J. Gray for sharing working memory data; and R. Poldrack for sharing response selection data (available at https://openfmri.org/). This research was supported by grants R01 HL089850 to P.J.G.; P01 HL040962 to S.B.M.; grants OCI-1131801, R01 DA035484, and R01 MH076136 to T.D.W.; JSPS-FWO grant VS.014.13 N to L.V.O. and S. Fukudo; JSPS-KAKENHI grant 26460898 to M.K.; R01 MH076137 and R01 AG043463 to K.O.; by the Direction de la Recherche Clinique of the University Hospital of Grenoble Alpes; and by the pharmaceutical labs Ferring and Cephalon. L.V.O. is funded by the KU Leuven Special Research Fund. T.E.N. is supported by the Wellcome Trust.
Publisher Copyright:
© 2017 The Author(s).
PY - 2018/2/1
Y1 - 2018/2/1
N2 - The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for medial frontal cortex representations that generalize across studies and subdomains but are specific to distinct psychological domains rather than reducible to a single underlying process.
AB - The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for medial frontal cortex representations that generalize across studies and subdomains but are specific to distinct psychological domains rather than reducible to a single underlying process.
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U2 - 10.1038/s41593-017-0051-7
DO - 10.1038/s41593-017-0051-7
M3 - Article
C2 - 29292378
AN - SCOPUS:85039781072
VL - 21
SP - 283
EP - 289
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 2
ER -