General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen

Atsushi Numata, Yoshinori Kondo, Takao Sakamoto

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.

Original languageEnglish
Pages (from-to)306-311
Number of pages6
JournalSynthesis
Issue number2
Publication statusPublished - 1999 Jan 1

Keywords

  • Cyclization
  • Lithiation
  • N-oxides
  • Naphthyridines
  • Palladium-catalyzed acetylene cross- coupling

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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