General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen

Atsushi Numata; Yoshinori Kondo; Takao Sakamoto

General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen

Atsushi Numata, Yoshinori Kondo, Takao Sakamoto

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.

Original language	English
Pages (from-to)	306-311
Number of pages	6
Journal	Synthesis
Issue number	2
Publication status	Published - 1999 Jan 1

Keywords

Cyclization
Lithiation
N-oxides
Naphthyridines
Palladium-catalyzed acetylene cross- coupling

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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title = "General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen",

abstract = "Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.",

keywords = "Cyclization, Lithiation, N-oxides, Naphthyridines, Palladium-catalyzed acetylene cross- coupling",

author = "Atsushi Numata and Yoshinori Kondo and Takao Sakamoto",

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AU - Numata, Atsushi

AU - Kondo, Yoshinori

AU - Sakamoto, Takao

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.

AB - Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.

KW - Cyclization

KW - Lithiation

KW - N-oxides

KW - Naphthyridines

KW - Palladium-catalyzed acetylene cross- coupling

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SN - 0039-7881

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ER -

General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen

Abstract

Keywords

ASJC Scopus subject areas

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