General Intelligence Is Associated with Working Memory-Related Functional Connectivity Change: Evidence from a Large-Sample Study

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Daniele Magistro, Ryuta Kawashima

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Purpose: Psychometric intelligence is closely related to working memory (WM) and the associated brain activity. We aimed to clarify the associations between psychometric intelligence and WM-induced functional connectivity changes. Materials and Methods: Here we determined the associations between psychometric intelligence measured by nonverbal reasoning (using the Raven's Advanced Progressive Matrices) and WM-induced changes in functional connectivity during the N-back paradigm, in a large cohort of 1221 young adults. Results: We observed that the measures of general intelligence showed a significant positive correlation with WM-induced changes in the functional connectivity with the key nodes of the frontoparietal network, such as the bilateral premotor cortices and the presupplementary motor area. Those significant correlations were observed for (1) areas showing a WM-induced increase of the functional connectivity with the abovementioned key nodes, such as the lateral parietal cortex; (2) areas showing a WM-induced decrease of the functional connectivity with the abovementioned key nodes (2-A) such as left perisylvian areas and cuneus, the fusiform gyrus, and the lingual gyrus, which play key roles in language processing, (2-b) hippocampus and parahippocampal gyrus, which play key roles in memory processing, and (2-c) the key node of the default mode network such as the medial prefrontal cortex; as well as (3) the border areas between (1) and (2). Conclusion: Psychometric intelligence is associated with WM-induced changes in functional connectivity, influencing the way in which WM key nodes dynamically modulate the interaction with other brain nodes in response to WM.

Original languageEnglish
Pages (from-to)89-102
Number of pages14
JournalBrain Connectivity
Volume11
Issue number2
DOIs
Publication statusPublished - 2021 Mar

Keywords

  • N-back task
  • functional connectivity
  • intelligence
  • psychophysiological interaction
  • working memory

ASJC Scopus subject areas

  • Neuroscience(all)

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