TY - JOUR
T1 - Gene Structure of Cytochrome P-450(M-1) Specifically Expressed in Male Rat Liver
AU - Morishima, Nobuhiro
AU - Yoshioka, Hidefumi
AU - Higashi, Yujiro
AU - Sogawa, Kazuhiro
AU - Fujii-Kuriyama, Yoshiaki
AU - Morishima, Nobuhiro
AU - Yoshioka, Hidefumi
AU - Sogawa, Kazuhiro
AU - Fujii-Kuriyama, Yoshiaki
PY - 1987
Y1 - 1987
N2 - Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706–1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5’-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.
AB - Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706–1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5’-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.
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U2 - 10.1021/bi00399a039
DO - 10.1021/bi00399a039
M3 - Article
C2 - 2894840
AN - SCOPUS:0023573045
VL - 26
SP - 8279
EP - 8285
JO - Biochemistry
JF - Biochemistry
SN - 0006-2960
IS - 25
ER -