Gene Structure of Cytochrome P-450(M-1) Specifically Expressed in Male Rat Liver

Nobuhiro Morishima; Hidefumi Yoshioka; Yujiro Higashi; Kazuhiro Sogawa; Yoshiaki Fujii-Kuriyama; Nobuhiro Morishima; Hidefumi Yoshioka; Kazuhiro Sogawa; Yoshiaki Fujii-Kuriyama

doi:10.1021/bi00399a039

Gene Structure of Cytochrome P-450(M-1) Specifically Expressed in Male Rat Liver

Nobuhiro Morishima, Hidefumi Yoshioka, Yujiro Higashi, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama, Nobuhiro Morishima, Hidefumi Yoshioka, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama

Research output: Contribution to journal › Article › peer-review

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Abstract

Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706–1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5’-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.

Original language	English
Pages (from-to)	8279-8285
Number of pages	7
Journal	Biochemistry
Volume	26
Issue number	25
DOIs	https://doi.org/10.1021/bi00399a039
Publication status	Published - 1987

ASJC Scopus subject areas

Biochemistry

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title = "Gene Structure of Cytochrome P-450(M-1) Specifically Expressed in Male Rat Liver",

abstract = "Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706–1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5{\textquoteright}-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.",

author = "Nobuhiro Morishima and Hidefumi Yoshioka and Yujiro Higashi and Kazuhiro Sogawa and Yoshiaki Fujii-Kuriyama and Nobuhiro Morishima and Hidefumi Yoshioka and Kazuhiro Sogawa and Yoshiaki Fujii-Kuriyama",

year = "1987",

doi = "10.1021/bi00399a039",

language = "English",

volume = "26",

pages = "8279--8285",

journal = "Biochemistry",

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publisher = "American Chemical Society",

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AU - Morishima, Nobuhiro

AU - Yoshioka, Hidefumi

AU - Higashi, Yujiro

AU - Sogawa, Kazuhiro

AU - Fujii-Kuriyama, Yoshiaki

AU - Morishima, Nobuhiro

AU - Yoshioka, Hidefumi

AU - Sogawa, Kazuhiro

AU - Fujii-Kuriyama, Yoshiaki

PY - 1987

Y1 - 1987

N2 - Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706–1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5’-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.

AB - Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706–1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5’-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.

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Gene Structure of Cytochrome P-450(M-1) Specifically Expressed in Male Rat Liver

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