Gene Structure of Cytochrome P-450(M-1) Specifically Expressed in Male Rat Liver

Nobuhiro Morishima, Hidefumi Yoshioka, Yujiro Higashi, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama, Nobuhiro Morishima, Hidefumi Yoshioka, Kazuhiro Sogawa, Yoshiaki Fujii-Kuriyama

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    44 Citations (Scopus)

    Abstract

    Cytochrome P-450(M-1) [P-450(M-1)] is specifically expressed in adult male rat liver [Yoshioka, H., Morohashi, K., Sogawa, K., Miyata, T., Kawajiri, K., Hirose, T., Inayama, S., Fujii-Kuriyama, Y., & Omura, T. (1987) J. Biol. Chem. 262, 1706–1711]. Isolation and analysis of the gene for P-450(M-1) revealed that the coding region of the gene is interrupted by eight introns and is dispersed over a 35-kilobase pair region of chromosomal DNA. Intron insertion sites of the P-450(M-1) gene are located at equivalent positions to those of cytochrome P-450b and P-450e, which are phenobarbital-inducible. Sequence analysis of the 5’-upstream region of the P-450(M-1) gene shows that there is a homologous sequence to glucocorticoid regulatory elements (GRE) identified in glucocorticoid-responsive genes.

    Original languageEnglish
    Pages (from-to)8279-8285
    Number of pages7
    JournalBiochemistry
    Volume26
    Issue number25
    DOIs
    Publication statusPublished - 1987

    ASJC Scopus subject areas

    • Biochemistry

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    Morishima, N., Yoshioka, H., Higashi, Y., Sogawa, K., Fujii-Kuriyama, Y., Morishima, N., Yoshioka, H., Sogawa, K., & Fujii-Kuriyama, Y. (1987). Gene Structure of Cytochrome P-450(M-1) Specifically Expressed in Male Rat Liver. Biochemistry, 26(25), 8279-8285. https://doi.org/10.1021/bi00399a039