TY - JOUR
T1 - Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction
T2 - The Ohasama study
AU - Takami, Seiju
AU - Imai, Yutaka
AU - Katsuya, Tomohiro
AU - Ohkubo, Takayoshi
AU - Tsuji, Ichiro
AU - Nagai, Kenichi
AU - Satoh, Hiroshi
AU - Hisamichi, Shigeru
AU - Higaki, Jitsuo
AU - Ogihara, Toshio
N1 - Funding Information:
This work was supported by a research grant from Takeda Medical Foundation, by a research grant entitled “Evaluation of the effect of drug treatment on hypertension and other chronic disease conditions in the elderly” from the Ministry of Health and Welfare, and by research grants for Scientific Research (07670746 and 07670420) from the Ministry of Education, Science and Culture of Japan. Original Communications
PY - 2000/2
Y1 - 2000/2
N2 - The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we conducted an association study in an Ohasama population, which is the cohort in a rural region of northern Japan. A total of 134 subjects without major neurological, cardiovascular, or metabolic disorders were recruited. Using brain magnetic resonance imaging, the number of lacunae in each of four brain regions were calculated, and periventricular hyperintensity was classified into five grades. We used the following four candidate gene polymorphisms: angiotensin converting enzyme (ACE)/Insertion(I)-Deletion(D), angiotensinogen (AGT)/M235T, angiotensin II type 1 receptor (AT1)/A1166C, type 2 receptor (AT2)/C3123A, to examine the association between polymorphisms and the severity of lacunar infarction. AGT/M235T was significantly associated with the number of lacunae in the brain stem, the basal ganglia (P < .05), and whole brain (P < .005) regions. The AT1 polymorphism was also significantly associated with the number of lacunae in the basal ganglia and whole brain regions (P < .05), and with periventricular hyperintensity grade (P < .005) in the younger population. However, ACE and AT2 polymorphisms failed to show an association with either the number of lacunae or the PVH grade. We concluded that AGT and AT1 polymorphisms are independent genetic risk factors for lacunar infarction. (C) 2000 American Journal of Hypertension, Ltd.
AB - The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we conducted an association study in an Ohasama population, which is the cohort in a rural region of northern Japan. A total of 134 subjects without major neurological, cardiovascular, or metabolic disorders were recruited. Using brain magnetic resonance imaging, the number of lacunae in each of four brain regions were calculated, and periventricular hyperintensity was classified into five grades. We used the following four candidate gene polymorphisms: angiotensin converting enzyme (ACE)/Insertion(I)-Deletion(D), angiotensinogen (AGT)/M235T, angiotensin II type 1 receptor (AT1)/A1166C, type 2 receptor (AT2)/C3123A, to examine the association between polymorphisms and the severity of lacunar infarction. AGT/M235T was significantly associated with the number of lacunae in the brain stem, the basal ganglia (P < .05), and whole brain (P < .005) regions. The AT1 polymorphism was also significantly associated with the number of lacunae in the basal ganglia and whole brain regions (P < .05), and with periventricular hyperintensity grade (P < .005) in the younger population. However, ACE and AT2 polymorphisms failed to show an association with either the number of lacunae or the PVH grade. We concluded that AGT and AT1 polymorphisms are independent genetic risk factors for lacunar infarction. (C) 2000 American Journal of Hypertension, Ltd.
KW - Genetics
KW - Lacunar infarction
KW - Periventricular hyperintensity (PVH)
KW - Polymorphism
KW - Renin angiotensin system
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U2 - 10.1016/S0895-7061(99)00184-3
DO - 10.1016/S0895-7061(99)00184-3
M3 - Article
C2 - 10701810
AN - SCOPUS:17344393902
VL - 13
SP - 121
EP - 127
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 2
ER -