Gene expression regulation and domain function of hematopoietic GATA factors

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49 Citations (Scopus)

Abstract

The hierarchical gene regulatory network in hematopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume16
Issue number1
DOIs
Publication statusPublished - 2005 Feb

Keywords

  • Complementation rescue
  • GATA-1
  • GATA-2
  • Gene regulatory networks

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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