Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury

Gi Wook Hwang, Jin Yong Lee, Katsunori Ryoke, Fujio Matsuyama, Jong Mu Kim, Tsutomu Takahashi, Akira Naganuma

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

To elucidate the molecular mechanism involved in methylmercury-induced cerebellar disorder, we performed DNA microarray analysis of the cerebellum of methylmercury-treated mice. The expression levels of 21 genes were elevated 2-fold or higher in response to methylmercury, including many genes encoding proteins involved in inflammatory reactions associated with chemokines. The expression levels of 11 genes were reduced by half or more in response to methylmercury.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalJournal of Toxicological Sciences
Volume36
Issue number3
DOIs
Publication statusPublished - 2011 Jun 1

Keywords

  • Cerebellum
  • Chemokines
  • Gene expression
  • Methylmercury
  • Mice

ASJC Scopus subject areas

  • Toxicology

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  • Cite this

    Hwang, G. W., Lee, J. Y., Ryoke, K., Matsuyama, F., Kim, J. M., Takahashi, T., & Naganuma, A. (2011). Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury. Journal of Toxicological Sciences, 36(3), 389-391. https://doi.org/10.2131/jts.36.389