Gene expression profiling in whole cerebral cortices of phencyclidine- or methamphetamine-treated rats

Yuta Ouchi, Yasuhiko Kubota, Atsuo Kuramasu, Takehiko Watanabe, Chihiro Ito

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Both phencyclidine (PCP) and methamphetamine (MAP) can cause schizophrenia-like symptoms. To identify the molecules relating to the drug-induced psychotic state, we used serial analysis of gene expression in rodent cerebral cortices isolated 1 h after intraperitoneal injection of saline, PCP (10 mg/kg), or MAP (4 mg/kg). We analyzed a total of 150,000 tags and found significantly up- or down-regulated genes. The number of MAP-, PCP-, and MAP and PCP-reactive tags were 229, 215, and 41, respectively.

Original languageEnglish
Pages (from-to)142-149
Number of pages8
JournalMolecular Brain Research
Volume140
Issue number1-2
DOIs
Publication statusPublished - 2005 Oct 31

Keywords

  • Cerebral cortex
  • Methamphetamine
  • Phencyclidine
  • Schizophrenia: serial analysis of gene expression (SAGE)

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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