Gene expression profiles induced by amphetamine and phencyclidine; novel targets for the treatment of drug psychosis and schizophrenia

Chihiro Ito, Yuta Ouchi

Research output: Contribution to journalReview article

Abstract

Although the aetiology of drug psychosis or schizophrenia is still unknown, molecular and biochemical researches have recently made significant advances in the search for the candidate genes of these disorders. Among such studies are animal models of drug psychosis or schizophrenia such as amphetamine-induced behavioural sensitisation or phencyclidine-treated animals. In this review, it is suggested that amphetamine or phencyclidine change the gene expressions related to cell damage/neuroplasticity. These alterable gene expressions may lead to the discovery for candidate genes of drug psychosis or schizophrenia and thus to novel antipsychotics.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalMedicinal Chemistry Reviews - Online
Volume2
Issue number1
Publication statusPublished - 2005 Feb 1

Keywords

  • Amphetamine
  • DNA array
  • Gene chip
  • Phencyclidine
  • Schizophrenia
  • Serial analysis of gene expression (SAGE)

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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