Gene expression of fibroblast growth factor receptors in the tissues of human gliomas and meningiomas

Jun A. Takahashi, Hiroshi Suzui, Yosiko Yasuda, Nobuyuki Ito, Mitsuhiro Ohta, Michael Jaye, Manabu Fukumoto, Yoshifumi Oda, Haruhiko Kikuchi, Masakazu Hatanaka

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Northern blot analysis showed transcripts of two types of the fibroblast growth factor (FGF) receptor genes, fig and bek, in almost all the tissues samples of 18 human gliomas and 22 human meningiomas, which produced abundant basic and/or acidic FGF. From immunohistochemistry, FGF receptors were expressed in the tumor cells of a glioma and a meningioma. RNA expression of these FGF receptors was also detectable in normal human brains and normal bovine meninges. The expression level of either FGF receptor gene was not significantly different between tumor tissues and normal tissues.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalBiochemical and biophysical research communications
Volume177
Issue number1
DOIs
Publication statusPublished - 1991 May 31

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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