Gene expression-based prognostic and predictive markers for breast cancer: A primer for practicing pathologists

Chungyeul Kim, Yusuke Taniyama, Soonmyung Paik

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Context. - Gene expression-based prognostic assays for breast cancer are now available as commercial reference laboratory tests covered by insurance. Objective. - To provide practicing pathologists with information about the nature of these assays, differences among them, and their use by clinical oncologists in the management of patients diagnosed with breast cancer. Data Sources. - Review of literature and unpublished data from the National Surgical Adjuvant Breast and Bowel Project. This review focused on a general conceptual description of the technology behind these assays and differences among them to aid understanding by pathologists in practice. Conclusions. - While these assays are clinically useful, they are still evolving. The future development of gene expression-based markers will need to be more clinical-context-specific to be clinically useful.

Original languageEnglish
Pages (from-to)855-859
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume133
Issue number6
Publication statusPublished - 2009 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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