Gene and protein expressions of type I collagen are regulated tissue-specifically in rat hyaline cartilages in vivo

Yasuyuki Sasano, Ichiro Takahashi, Jing Xu Zhu, Haruo Ohtani, Itaru Mizoguchi, Manabu Kagayama

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The present study was designed to investigate how rat hyaline cartilages at various sites in vivo express the gene and protein of type I collagen using in situ hybridization and immuno-histochemistry. The gene of pro alpha 1(I) collagen was expressed by chondrocytes in articular cartilage, and the protein of type I collagen was identified in the cartilage matrix. In contrast, growth plate cartilage expressed the gene of pro alpha 1(I) collagen, but no protein of type I collagen. Neither gene nor protein of type I collagen was expressed in cartilages of trachea and nasal septum. The present study suggested that expression of type I collagen in hyaline cartilages may be regulated tissue-specifically at gene and/or protein levels.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalEuropean Journal of Morphology
Volume39
Issue number3
DOIs
Publication statusPublished - 2001 Dec 1

Keywords

  • Articular cartilage
  • Growth plate cartilage
  • Immunohistochemistry
  • In situ hybridization
  • Nasal septum cartilage
  • Tracheal cartilage
  • Type I collagen

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)

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