Gender differences in partial-volume corrected brain perfusion using brain MRI in healthy children

Yasuyuki Taki, Hiroshi Hashizume, Yuko Sassa, Hikaru Takeuchi, Kai Wu, Michiko Asano, Kohei Asano, Hiroshi Fukuda, Ryuta Kawashima

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


To investigate gender differences in brain perfusion, this study utilized pulsed arterial spin-labeling magnetic resonance imaging (MRI) in a large number of healthy children. Data on structural and perfusion MRI in the brain were collected from 202 healthy children aged 5-18 years. Gender differences in brain perfusion using partial volume correction (PVC), which was calculated by dividing the normalized perfusion MRI by the normalized gray-matter segments, were analyzed by applying voxel-based analysis and region-of-interest (ROI) analysis. Girls showed significantly higher brain perfusion with PVC in the bilateral medial aspect of the parietal lobes, including the posterior cingulate cortex and precuneus, as compared to boys using voxel-based analysis. In addition, brain perfusion with PVC in the bilateral posterior cingulate cortex, bilateral precuneus, and left thalamus was significantly higher in girls than in boys in the ROI analysis. In contrast, no regions were seen in which boys exhibited higher brain perfusion with PVC than girls in both analyses. The findings showed significant differences between boys and girls in brain perfusion with PVC, and these differences may contribute to gender differences in the cognitive ability of healthy children.

Original languageEnglish
Pages (from-to)709-715
Number of pages7
Issue number3
Publication statusPublished - 2011 Oct 1


  • Arterial spin labeling
  • Brain perfusion
  • Children
  • Gender differences
  • Gray matter
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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