Differenze di genere nelle anomalie funzionali coronariche

Translated title of the contribution: Gender differences in coronary functional abnormalities

Kensuke Nishimiya, Hiroaki Shimokawa

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


The ISCHEMIA trial demonstrated that coronary revascularization strategies may not necessarily improve the long-term prognosis of patients with obstructive coronary artery disease, suggesting the significance of the remaining coronary functional abnormalities. Recently, more attention has been paid to ischemia with no obstructive coronary artery (INOCA) disease, due to the poor prognosis as showed in sev-eral cohorts. Coronary microvascular dysfunction (CMD) and epicardial coronary spasm have been proposed as the main causes of INOCA. While gender difference was not significant in the prognosis of patients with epicardial spasm, a poor prognosis was identified in women with CMD. In the last de-cade, efforts have been made to clarify the connection between these coronary functional abnormalities and an im-paired prognosis. In this article, we will briefly review the recent advances in gender medicine regarding coronary functional abnormalities, including CMD and epicardial spasm.

Translated title of the contributionGender differences in coronary functional abnormalities
Original languageItalian
Pages (from-to)15-21
Number of pages7
JournalItalian Journal of Gender-Specific Medicine
Issue number1
Publication statusPublished - 2021
Externally publishedYes


  • Coronary artery spasm
  • Coronary microvascular dysfunction
  • Microvas-cular spasm
  • Vasospastic angina

ASJC Scopus subject areas

  • Gender Studies


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