Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety

Tomoko Mizuno, Masashi Aoki, Yuko Shimada, Midori Inoue, Kumi Nakaya, Toshiaki Takahashi, Yasuto Itoyama, Motoyori Kanazawa, Atsushi Utsumi, Yuka Endo, Taisuke Nomura, Masahiro Hiratsuka, Michinao Mizugaki, Junichi Goto, Michio Hongo, Shin Fukudo

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Objective: The objective of this study was to verify the hypothesis that variation of the serotonin transporter gene promoter region (5-HTTLPR) is associated with sensitivity to stress. Methods: Genotyping of 5-HTTLPR and evaluation of emotional states were performed on 194 participants. Participants' emotional states were evaluated using the Perceived-Stress Scale (PSS), the State-Trait Anxiety Inventory (STAI), and the Self-rating Depression Scale (SDS). Results: There was significant Gender×Genotype interaction in STAI (state, P<.05; trait, P<.05). Females with the l/s genotype showed higher anxiety than those with the s/s genotype in both state and trait anxiety. Oppositely, males with the s/s genotype showed higher anxiety than those with the l/s genotype. Conclusion: On all emotional scales, females with the l/s genotype showed high scores, contrary to males with the same genotype. Therefore, our results suggest that 5-HTTLPR l allele may be one pathway that activates negative emotion in females but acts contrary in males.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalJournal of Psychosomatic Research
Volume60
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

Keywords

  • Anxiety
  • Depression
  • Gender
  • Gene (serotonin transporter promoter polymorphism)
  • Serotonin
  • Stress

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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