GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation

Kyohei Ariake, Hideo Ohtsuka, Fuyuhiko Motoi, Daisuke Douchi, Masaya Oikawa, Toshiki Rikiyama, Koji Fukase, Yu Katayose, Shinichi Egawa, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

The precise relationship between GCF2 expression and carcinogenesis has not yet been established. To clarify the metastatic potential of GCF2 in colorectal cancer, HT-29 cells stably suppressing GCF2 expression were injected into the spleens of severe combined immunodeficient (SCID) mice. GCF2 suppression reduced the number of metastatic foci in the liver and reduced fibronectin-induced cell adhesion, migration, and invasion. Downstream from the integrin signaling pathways, GCF2 regulates RhoA interaction with the RGS domain of Leukemia associated RhoGEF (LARG). Altogether, our results suggest that GCF2 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion, migration, and invasion.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalCancer Letters
Volume325
Issue number1
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

Keywords

  • Colorectal cancer
  • GCF2
  • Integrin
  • LRRFIP1
  • RhoA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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