Abstract
Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.
Original language | English |
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Pages (from-to) | 31087-31093 |
Number of pages | 7 |
Journal | Journal of Biological Chemistry |
Volume | 285 |
Issue number | 41 |
DOIs | |
Publication status | Published - 2010 Oct 8 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology