GATA switches as developmental drivers

Emery H. Bresnick, Hsiang Ying Lee, Tohru Fujiwara, Kirby D. Johnson, Sunduz Keles

Research output: Contribution to journalShort surveypeer-review

187 Citations (Scopus)

Abstract

Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.

Original languageEnglish
Pages (from-to)31087-31093
Number of pages7
JournalJournal of Biological Chemistry
Volume285
Issue number41
DOIs
Publication statusPublished - 2010 Oct 8

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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