GATA switches as developmental drivers

Emery H. Bresnick; Hsiang Ying Lee; Tohru Fujiwara; Kirby D. Johnson; Sunduz Keles

doi:10.1074/jbc.R110.159079

GATA switches as developmental drivers

Emery H. Bresnick, Hsiang Ying Lee, Tohru Fujiwara, Kirby D. Johnson, Sunduz Keles

Central Clinical Facilities

Research output: Contribution to journal › Short survey › peer-review

187 Citations (Scopus)

Abstract

Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.

Original language	English
Pages (from-to)	31087-31093
Number of pages	7
Journal	Journal of Biological Chemistry
Volume	285
Issue number	41
DOIs	https://doi.org/10.1074/jbc.R110.159079
Publication status	Published - 2010 Oct 8

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.",

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AU - Bresnick, Emery H.

AU - Lee, Hsiang Ying

AU - Fujiwara, Tohru

AU - Johnson, Kirby D.

AU - Keles, Sunduz

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AB - Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.

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