Gastrointestinal transit and stress response after laparoscopic vs conventional distal pancreatectomy in the canine model

Takeshi Naito, A. Garcia-Ruiz, A. Vladisavljevic, S. Matsuno, M. Gagner

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Background: Several authors have presented the feasibility of laparoscopic pancreatic surgery. However, the pathophysiological effect of laparoscopic pancreatic surgery is not well known. Methods: Ten mongrel dogs were randomly operated for laparoscopic and conventional distal pancreatectomy. Fed state gastrointestinal transit times were assessed using radiopaque markers. To assess surgical stress, we determined serum IL-1 and cortisol. Results: Postoperative mouth-to-anus transit time in the laparoscopic group was not prolonged while it was significantly prolonged in the conventional group compared with the baseline study, but no significant differences between groups were detected. First defecation was observed significantly earlier in the laparoscopic group. Serum cortisol levels were elevated significantly at 4 h after skin incision in both groups and decreased thereafter. In the laparoscopic group, they returned close to the normal level at 8 h after incision, but were still significantly higher in the conventional group. The level of IL-1 was elevated significantly higher in conventional group at 24 h after the skin incision. Conclusion: Thus, we conclude that laparoscopic distal pancreatectomy demonstrated faster recovery of the bowel transit and less stress than conventional distal pancreatectomy in dogs.

Original languageEnglish
Pages (from-to)1627-1630
Number of pages4
JournalSurgical Endoscopy and Other Interventional Techniques
Volume16
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Keywords

  • Gastrointestinal transit
  • Laparoscopic
  • Pancreatectomy
  • Stress response
  • Surgery

ASJC Scopus subject areas

  • Surgery

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