Gastroesophageal Reflux Disease-Related Disorders of Systemic Sclerosis Based on the Analysis of 66 Patients

Rie Matsuda, Nobutake Yamamichi, Takeshi Shimamoto, Hayakazu Sumida, Yu Takahashi, Chihiro Minatsuki, Shinya Kodashima, Satoshi Ono, Keiko Niimi, Yosuke Tsuji, Yoshiki Sakaguchi, Itaru Saito, Yosuke Kataoka, Itsuko Asada-Hirayama, Hikaru Kakimoto, Seiichi Yakabi, Chihiro Takeuchi, Yuta Matsumoto, Zenshiro Tamaki, Mitsuhiro FujishiroYoshihide Asano, Shinichi Sato, Kazuhiko Koike

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background/Aims: Gastroesophageal reflux disease (GERD)-related disorders of systemic sclerosis (SSc) patients have not been adequately investigated. Methods: Sixty-six SSc patients (5 males and 61 females; 56.6 ± 14.6 years old) who underwent esophagogastroduodenoscopy were analyzed on the basis of 16 background factors. They were additionally compared with 116 matched non-SSc subjects controlling age, sex, and use of proton pump inhibitors (PPIs). Results: The mean disease duration of 66 patients was 5.1 ± 8.1 years, and their breakdown was as follows: 53 (80.3%) with GERD, 38 (57.6%) with GERD-related symptoms, and 20 (30.3%) with reflux esophagitis (RE; LA-A: 10, LA-B: 5, LA-C: 4, LA-D: 1). Use of PPI (p = 0.0455), complication of interstitial lung disease (p = 0.0242), and history of cyclophosphamide therapy (p = 0.0184) denoted significant association with GERD-related symptoms. Older age (p = 0.0211) was significantly associated with RE. None of GERD-related disorders showed any difference between 37 diffuse cutaneous SSc and 29 limited cutaneous SSc patients. The matched analysis indicated that SSc patients had higher prevalence of GERD (p < 0.0001), GERD-related symptoms (p = 0.0034), and RE (p = 0.0002). Conclusion: SSc patients tend to have worse GERD symptoms and severer RE. However, most SSc-Associated factors did not show significant association with GERD-related disorders, indicating the difficulty in predicting GERD-related disorders among SSc patients.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
Issue number4
Publication statusPublished - 2018 Nov 1
Externally publishedYes


  • Frequency scale for the symptoms of gastroesophageal reflux disease
  • Gastroesophageal reflux disease
  • Los Angeles classification of gastroesophageal reflux
  • Non-erosive reflux disease
  • Reflux esophagitis
  • Systemic sclerosis

ASJC Scopus subject areas

  • Gastroenterology


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