Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome

Shigemi Ito, Toru Tase, Kennichi Satoh, Miyuki Ueki, Ikuro Sato, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In this report, unique endocervical glandular lesions exhibiting gastric differentiation were examined in a patient with Peutz-Jeghers syndrome. The result of the human papillomavirus (HPV) in situ hybridization (ISH) for the hysterectomy specimens was negative, but they demonstrated a papillary mucinous adenocarcinoma at the proximal endocervix continuous to atypical lobular endocervical glandular hyperplasia. Both contained MUC6-positive neutral mucin in cytoplasm, and showed different immunoreactivity to p16, Ki-67, and p53. Moreover, they harbored the identical K-RAS gene mutation suggesting that there was a common origin. Somatic K-RAS mutation and defective function of p16 may have been involved in the tumorigenesis of these unusual mucinous neoplasms.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalPathology international
Volume64
Issue number6
DOIs
Publication statusPublished - 2014 Jun

Keywords

  • Cervical adenocarcinoma
  • K-RAS
  • Lobular endocervical glandular hyperplasia
  • P16
  • Peutz-Jeghers syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome'. Together they form a unique fingerprint.

Cite this