Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy

Yasuhiro Nakamura, Setsuya Otani, Michiro Otaka, Tomoyuki Shimada, Satsuki Takahashi, Masahiro Saito, Tohru Takahashi, Masahumi Komatsu, Toshie Suzuki, Shunji Okubo, Masato Hayashi, Hironobu Sasano

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    We report a patient with gastric small cell carcinoma (SCC) who showed a marked response to neoadjuvant chemotherapy. The patient was a 72-year-old Japanese man who was admitted because of epigastralgia. Subsequent examination revealed the presence of advanced gastric carcinoma in the lesser curvature of the lower body of the stomach, with multiple abdominal lymph node metastases. Endoscopic biopsy specimens from the tumor revealed SCC with moderately differentiated adenocarcinoma. The patient received neoadjuvant chemotherapy consisting of carboplatin (400 mg/m2, for 1 day), epirubicin (27 mg/m2, for 1 day), etoposide (70 mg/m2, for 3 days), and 5-fluorouracil (330 mg/m2, for 11 days). Clinically, the primary tumor and lymph node metastases were markedly reduced. Subsequently the patient underwent curative surgery and was alive without recurrence for more than 3 years after the surgery.

    Original languageEnglish
    Pages (from-to)348-352
    Number of pages5
    JournalInternational Journal of Clinical Oncology
    Volume10
    Issue number5
    DOIs
    Publication statusPublished - 2005 Oct

    Keywords

    • Adenocarcinoma
    • Neoadjuvant chemotherapy
    • Small cell carcinoma
    • Stomach

    ASJC Scopus subject areas

    • Surgery
    • Hematology
    • Oncology

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