Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

Wei ming Shian, Iwao Sasaki, Yasuhiko Kamiyama, Hiroo Naito, Yuji Funayama, Seiki Matsuno, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalTohoku Journal of Experimental Medicine
Volume176
Issue number2
DOIs
Publication statusPublished - 1995

Keywords

  • CLHPLC method
  • cold water-immersion restraint stress
  • gastric mucosal lesions
  • lipid peroxidation
  • phosphatidylcholine hydroperoxides (PCOOH)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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