Abstract
To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.
Original language | English |
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Pages (from-to) | 127-130 |
Number of pages | 4 |
Journal | Tohoku Journal of Experimental Medicine |
Volume | 176 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1995 |
Keywords
- CLHPLC method
- cold water-immersion restraint stress
- gastric mucosal lesions
- lipid peroxidation
- phosphatidylcholine hydroperoxides (PCOOH)
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)