Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

Wei ming Shian; Iwao Sasaki; Yasuhiko Kamiyama; Hiroo Naito; Yuji Funayama; Seiki Matsuno; Teruo Miyazawa

doi:10.1620/tjem.176.127

Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

Wei ming Shian, Iwao Sasaki, Yasuhiko Kamiyama, Hiroo Naito, Yuji Funayama, Seiki Matsuno, Teruo Miyazawa

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	Tohoku Journal of Experimental Medicine
Volume	176
Issue number	2
DOIs	https://doi.org/10.1620/tjem.176.127
Publication status	Published - 1995

Keywords

CLHPLC method
cold water-immersion restraint stress
gastric mucosal lesions
lipid peroxidation
phosphatidylcholine hydroperoxides (PCOOH)

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1620/tjem.176.127

Cite this

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abstract = "To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.",

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AU - Shian, Wei ming

AU - Sasaki, Iwao

AU - Kamiyama, Yasuhiko

AU - Naito, Hiroo

AU - Funayama, Yuji

AU - Matsuno, Seiki

AU - Miyazawa, Teruo

PY - 1995

Y1 - 1995

N2 - To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

AB - To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

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KW - cold water-immersion restraint stress

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KW - lipid peroxidation

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Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

Abstract

Keywords

ASJC Scopus subject areas

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