Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

Wei ming Shian; Iwao Sasaki; Yasuhiko Kamiyama; Hiroo Naito; Yuji Funayama; Seiki Matsuno; Teruo Miyazawa

doi:10.1620/tjem.176.127

Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

Wei ming Shian, Iwao Sasaki, Yasuhiko Kamiyama, Hiroo Naito, Yuji Funayama, Seiki Matsuno, Teruo Miyazawa

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

Original language	English
Pages (from-to)	127-130
Number of pages	4
Journal	Tohoku Journal of Experimental Medicine
Volume	176
Issue number	2
DOIs	https://doi.org/10.1620/tjem.176.127
Publication status	Published - 1995

Keywords

CLHPLC method
cold water-immersion restraint stress
gastric mucosal lesions
lipid peroxidation
phosphatidylcholine hydroperoxides (PCOOH)

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1620/tjem.176.127

Cite this

Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats. / Shian, Wei ming; Sasaki, Iwao; Kamiyama, Yasuhiko; Naito, Hiroo; Funayama, Yuji; Matsuno, Seiki; Miyazawa, Teruo.

In: Tohoku Journal of Experimental Medicine, Vol. 176, No. 2, 1995, p. 127-130.

Research output: Contribution to journal › Article › peer-review

@article{0360e001be294154845bd07e8c2ca469,

title = "Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats",

abstract = "To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.",

keywords = "CLHPLC method, cold water-immersion restraint stress, gastric mucosal lesions, lipid peroxidation, phosphatidylcholine hydroperoxides (PCOOH)",

author = "Shian, {Wei ming} and Iwao Sasaki and Yasuhiko Kamiyama and Hiroo Naito and Yuji Funayama and Seiki Matsuno and Teruo Miyazawa",

year = "1995",

doi = "10.1620/tjem.176.127",

language = "English",

volume = "176",

pages = "127--130",

journal = "Tohoku Journal of Experimental Medicine",

issn = "0040-8727",

publisher = "Tohoku University Medical Press",

number = "2",

}

TY - JOUR

T1 - Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

AU - Shian, Wei ming

AU - Sasaki, Iwao

AU - Kamiyama, Yasuhiko

AU - Naito, Hiroo

AU - Funayama, Yuji

AU - Matsuno, Seiki

AU - Miyazawa, Teruo

PY - 1995

Y1 - 1995

N2 - To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

AB - To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.

KW - CLHPLC method

KW - cold water-immersion restraint stress

KW - gastric mucosal lesions

KW - lipid peroxidation

KW - phosphatidylcholine hydroperoxides (PCOOH)

UR - http://www.scopus.com/inward/record.url?scp=0029315542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029315542&partnerID=8YFLogxK

U2 - 10.1620/tjem.176.127

DO - 10.1620/tjem.176.127

M3 - Article

C2 - 7482523

AN - SCOPUS:0029315542

VL - 176

SP - 127

EP - 130

JO - Tohoku Journal of Experimental Medicine

JF - Tohoku Journal of Experimental Medicine

SN - 0040-8727

IS - 2

ER -

Gastric Mucosal Phosphatidylcholine Hydroperoxide Increases during Cold water-Immersion Restraint Stress in Rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this