Gastric acid secretion and serum gastrin levels in chronic pancreatitis

Toshio Sato, Jin ichi Kameyama, Iwao Sasaki, Mikio Imamura, Seiki Matsuno

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Of 114 patients with chronic pancreatitis, 19 (16.7%) has gastric or duodenal ulcers. Patients with moderate pancreatic exocrine dysfunction tended to show high acid output and low serum gastrin levels, while those with severe dysfunction had slightly lower acid output and higher serum gastrin levels. The higher the degree of pancreatic fib rosis, the higher tended to be the acid output and serum gastrin levels. Not all patients with ulcers developed hypergastrinemia. The mechanism of acid hypersecretion and ulcer formation in patients with chronic pancreatitis cannot be explained solely by pancreatic deterioration, fibrosis or gastrin release; a decrease in the production and release of gastric inhibitory hormone should be taken into consideration.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalGastroenterologia Japonica
Volume16
Issue number2
DOIs
Publication statusPublished - 1981 Apr 1

Keywords

  • chronic pancreatitis
  • gastric acid hypersecretion
  • gastric or duodenal ulcer
  • hypergastrinemia
  • pancreatic fibrosis

ASJC Scopus subject areas

  • Gastroenterology

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    Sato, T., Kameyama, J. I., Sasaki, I., Imamura, M., & Matsuno, S. (1981). Gastric acid secretion and serum gastrin levels in chronic pancreatitis. Gastroenterologia Japonica, 16(2), 93-99. https://doi.org/10.1007/BF02774382