Gastric acid secretion and gastrointestinal hormone release after biliary reconstruction procedures

Toshio Sato, Mikio Imamura, Iwao Sasaki, Jinichi Kameyama

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The changes in gastric acid secretion and gastrointestinal hormone release were studied after biliary tract reconstruction to investigate the mechanism of gastric acid hypersecretion after a biliary diversion procedure. At follow-up, gastric acid output in patients with Roux-Y choledochojejunostomy was significantly higher than before the operation. In contrast, in patients with jejunal interposition choledochoduodenostomy, which does not bring about biliary diversion, acid output increased slightly after the operation. Moreover, at follow-up, acid output in the Roux-Y group was slightly higher than it was in the interposition group. Although the fasting levels of plasma gastric inhibitory polypeptide were almost the same in both groups, the loading of a test meal elicited a lower response of plasma gastric inhibitory polypeptide in patients with the Roux-Y procedure than in those with the interposition procedure. Therefore, it is assumed that gastric inhibitory polypeptide, as an enterogastrone after a biliary reconstruction procedure, might have some influence on gastric acid secretion.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalThe American Journal of Surgery
Volume146
Issue number2
DOIs
Publication statusPublished - 1983 Aug

ASJC Scopus subject areas

  • Surgery

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