Gassericin A; an uncommon cyclic bacteriocin produced by lactobacillus gasseri LA39 linked at N- and C-terminal ends

Yasushi Kawai, Tadao Saito, Haruki Kitazawa, Takatoshi Itoh

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

Gassericin A, a bacteriocin that was produced by Lactobacillus gasseri LA39, was treated with lysylendopeptidase and 3-bromo-3-methyl-2-(2-nitrophenyl-mercapto)-3H-indole. The fragments were recovered by SDS-PAGE and sequenced. All amino acids of gassericin A were distributed by sequence analysis and the bacteriocin did not contain any modified amino acids. The amino acid sequence of gassericin A completely coincided with that found through the cloning of the structural gene. Gassericin A was shown to be a cyclic bacteriocin (class II) which is bound at the N- and C-terminal ends. This is the first example of a cyclic bacteriocin from lactobacilli lactic acid bacteria.

Original languageEnglish
Pages (from-to)2438-2440
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume62
Issue number12
DOIs
Publication statusPublished - 1998 Jan 1

Keywords

  • Acidocin B
  • Bacteriocin
  • Cyclic structure
  • Gassericin A
  • Lactobacillus gasseri

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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