Garcinone B reduces prostaglandin E2 release and NF-κB-mediated transcription in C6 rat glioma cells

Tohru Yamakuni, Koichi Aoki, Keigo Nakatani, Nobuhiko Kondo, Hisae Oku, Kyoko Ishiguro, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


In the course of our survey of natural compounds inhibiting prostaglandin E2 release and/or lipopolysaccharide (LPS)-induced transcriptional stimulation via NF-κB, a central regulator of inflammatory genes, from natural resources, we found garcinone B, a xanthone from callus tissue culture of Hypericum patulum, as a compound with such pharmacological activities, that is a derivative of γ-mangostin which potently inhibits COX-1 and COX-2 activities to reduce PGE2 release from C6 rat glioma cells, and inhibits IKK activity to prevent NF-κB-dependent COX-2 gene transcription. Garcinone B, to a lesser extent, reduced A23187-induced increase in prostaglandin E2 release than γ-mangostin and its structurally related compound, patulone, in C6 cells. This compound also prevented LPS-induced stimulation of NF-κB-dependent transcription. These results suggest that garcinone B becomes a unique pharmacological tool to investigate intracellular signaling pathways involved in inflammation.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 2006 Feb 20
Externally publishedYes


  • C6 rat glioma cells
  • Garcinone B
  • NF-κB-dependent transcription
  • Prostaglandin E release
  • Xanthones
  • γ-Mangostin

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Garcinone B reduces prostaglandin E2 release and NF-κB-mediated transcription in C6 rat glioma cells'. Together they form a unique fingerprint.

Cite this