Gallbladder Emptying to Endogenous and Exogenous Stimulation in Chronic Pancreatitis Patients

Takayoshi Meguro, Tooru Shimosegawa, Junya Kashimura, Yoshifumi Kikuchi, Masaru Koizumi, Takayoshi Toyota

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Objectives: The present study was designed to analyze the underlying mechanism of gallbladder motor disturbance in chronic pancreatitis patients. Methods: Gallbladder emptying to endogenous (oral test meal, Daiyan 13 g) and exogenous stimulation (iv cerulein, 30 ng/kg for 5 min) was examined by real‐time ultrasonography in 12 patients with chronic pancreatitis and 10 normal subjects (controls). Plasma cholecystokinin levels during the endogenous stimulation were measured by bioassay. Results: In chronic pancreatitis patients compared with controls, the fasting allbladder volume was significantly increased (29.5 ± 2.2 vs. 21.5 ± 2.8 ml), whereas the gallbladder emptying (percent change of the basal volume) to oral test meal was significantly decreased. Neither cholecystokinin secretion induced by the test meal, nor the gallbladder emptying response to intravenous cerulein, differed signiHcantly between the two groups. However, when chronic pancreatitis patients were divided according to pathogenesis, it became clear that gallbladder emptying to intravenous cerulein was significantly greater in patients with alcoholic chronic pancreatitis than in patients with idiopathic pancreatitis. Conclusions: Gallbladder emptying during the intestinal phase Is generally reduced in patients with chronic pancreatitis, but gallbladder responsiveness to exogenous stimulation might be heterogeneous according to the pathogenesis.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalThe American journal of gastroenterology
Issue number2
Publication statusPublished - 1994 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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