Gallbladder emptying and cholecystokinin and pancreatic polypeptide responses to a liquid meal in patients with diabetes mellitus

Takayoshi Meguro, Tooru Shimosegawa, Akihiko Satoh, Hitoshi Suzuki, Atsuko Takasu, Akira Takayama, Masaru Koizumi, Takayoshi Toyota

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

To investigate gallbladder motility and its regulation in patients with diabetes mellitus (DM), we examined the gallbladder response to an intraduodenal test meal by measuring the temporal course of plasma cholecystokinin (CCK) and pancreatic polypeptide (PP) levels. Eighteen patients with type 2 DM and 7 healthy subjects (controls) were enrolled. The gallbladder volume was calculated by the sum-of-cylinders method from ultrasonographic images, and plasma CCK and PP were measured by radioimmunoassays. No significant difference was found in either the gallbladder response or in the CCK response between patients with DM and controls. However, the fasting plasma PP level of patients with DM was more than tenfold higher than that of controls. The integrated PP response (IPPR) of patients with DM to the test meal was 8.3-fold higher than that of controls. When patients with DM were grouped according to whether they had been treated with insulin or not, the fasting plasma PP of patients with DM without insulin treatment was significantly higher than the level in those treated with insulin. These results suggest that overproduction of PP-like immunoreactive substance(s) may occur in patients with DM, but the high plasma PP immunoreactivity does not appear to be related to the fasting gallbladder volume or to gallbladder emptying and filling.

Original languageEnglish
Pages (from-to)628-634
Number of pages7
JournalJournal of gastroenterology
Volume32
Issue number5
DOIs
Publication statusPublished - 1997 Oct

Keywords

  • Cholecystokinin
  • Diabetes mellitus
  • Gallbladder emptying
  • Pancreatic polypeptide

ASJC Scopus subject areas

  • Gastroenterology

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