Galanin-immunoreactive nerve fibers in the periodontal ligament during experimental tooth movement

T. Deguchi; N. Takeshita; T. A. Balam; Y. Fujiyoshi; T. Takano-Yamamoto

doi:10.1177/154405910308200904

Galanin-immunoreactive nerve fibers in the periodontal ligament during experimental tooth movement

T. Deguchi, N. Takeshita, T. A. Balam, Y. Fujiyoshi, T. Takano-Yamamoto

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Neuropeptides have been suggested to play a role in pain transmission during orthodontic tooth movement. We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar. In control rats, GAL-ir fibers were very rare in the PDL. One day after the insertion of the elastic band, the number of GAL-ir fibers increased, becoming most numerous at 3 days. From 5 to 28 days, GAL-ir fibers tended to decrease. Electron microscopic observation showed that all of the GAL-ir fibers were unmyelinated. These findings suggest that GAL-containing nerve fibers in the PDL may play an important role in the response of the tissue to experimental tooth movement.

Original language	English
Pages (from-to)	677-681
Number of pages	5
Journal	Journal of dental research
Volume	82
Issue number	9
DOIs	https://doi.org/10.1177/154405910308200904
Publication status	Published - 2003 Sep
Externally published	Yes

Keywords

Galanin
Periodontal ligament
Rat
Tooth movement

ASJC Scopus subject areas

Dentistry(all)

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10.1177/154405910308200904

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title = "Galanin-immunoreactive nerve fibers in the periodontal ligament during experimental tooth movement",

abstract = "Neuropeptides have been suggested to play a role in pain transmission during orthodontic tooth movement. We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar. In control rats, GAL-ir fibers were very rare in the PDL. One day after the insertion of the elastic band, the number of GAL-ir fibers increased, becoming most numerous at 3 days. From 5 to 28 days, GAL-ir fibers tended to decrease. Electron microscopic observation showed that all of the GAL-ir fibers were unmyelinated. These findings suggest that GAL-containing nerve fibers in the PDL may play an important role in the response of the tissue to experimental tooth movement.",

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AU - Deguchi, T.

AU - Takeshita, N.

AU - Balam, T. A.

AU - Fujiyoshi, Y.

AU - Takano-Yamamoto, T.

PY - 2003/9

Y1 - 2003/9

N2 - Neuropeptides have been suggested to play a role in pain transmission during orthodontic tooth movement. We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar. In control rats, GAL-ir fibers were very rare in the PDL. One day after the insertion of the elastic band, the number of GAL-ir fibers increased, becoming most numerous at 3 days. From 5 to 28 days, GAL-ir fibers tended to decrease. Electron microscopic observation showed that all of the GAL-ir fibers were unmyelinated. These findings suggest that GAL-containing nerve fibers in the PDL may play an important role in the response of the tissue to experimental tooth movement.

AB - Neuropeptides have been suggested to play a role in pain transmission during orthodontic tooth movement. We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar. In control rats, GAL-ir fibers were very rare in the PDL. One day after the insertion of the elastic band, the number of GAL-ir fibers increased, becoming most numerous at 3 days. From 5 to 28 days, GAL-ir fibers tended to decrease. Electron microscopic observation showed that all of the GAL-ir fibers were unmyelinated. These findings suggest that GAL-containing nerve fibers in the PDL may play an important role in the response of the tissue to experimental tooth movement.

KW - Galanin

KW - Periodontal ligament

KW - Rat

KW - Tooth movement

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ER -

Galanin-immunoreactive nerve fibers in the periodontal ligament during experimental tooth movement

Abstract

Keywords

ASJC Scopus subject areas

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