GaCl3-Catalyzed ortho-ethynylation reaction of N-benzylanilines

Ryo Amemiya, Akiko Fujii, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Lithiated N-benzylanilines were ethynylated at the ortho-position with silylchloroethyne at 120°C in the presence of a catalytic amount of GaCl3. Trimethylsilylated N-methylaniline could also be used for this transformation.

Original languageEnglish
Pages (from-to)4333-4335
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number22
DOIs
Publication statusPublished - 2004 May 24

Keywords

  • Catalysis
  • Chloroethyne
  • Gallium(III) chloride
  • N-Benzylaniline
  • ortho-Ethynylation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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