G-cell hyperplasia of the stomach induces ECL-cell proliferation in the pyloric glands in a paracrinal manner

Atsuko Kasajima, Fumiyoshi Fujishima, Takanori Morikawa, Shuhei Kawasaki, Sachiko Konosu-Fukaya, Yukiko Shibahara, Tadaho Nakamura, Takeo Yoshikawa, Katsunori Iijima, Tomoyuki Koike, Mika Watanabe, Chikashi Shibata, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


An inhibitory mechanism toward gastrin hypersecretion is significantly different between G-cell hyperplasia and gastrinoma despite the common clinical manifestations; hypergastrinemia and its related persistent gastric ulcers. We recenlty studied the G-cell, d-cell and ECL-cell density in a case of G-cell hyperplasia. The 70-year-old patient has been treated for persistent gastric ulcers with a markedly increased plasma gastrin (5600pg/mL). The stomach was surgically resected because of the obstruction associated with ulcer scars. The number of G-cells in the pyloric glands was quantified on the surgical specimens and G-cell hyperplasia was histolopathologically identified. Immunostainig of histidine decarboxylate revealed the presence of ECL-cell hyperplasia in the pyloric glands and its density was significantly and positively correlated with G-cell density. Somatostatin immunoreactive cells (d-cells) increased in their number in the oxyntic glands. These results all indicated that hypersecretion of gastrin in G-cell hyperplasia could induce ECL-cell proliferation in a paracrinal manner. In addition, relatively non-prominent endocrinological features in the G-cell hyperplasia compared to gastrinoma could be also related to the paracrinal somatostatin inhibitory effects upon ECL-cells in the pyloric glands.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalPathology international
Issue number5
Publication statusPublished - 2015 May 1


  • ECL-cell hyperplasia
  • G-cell hyperplasia
  • Hypergastrinemia
  • Persistent ulcers

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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