Abstract
The current clamp and voltage clamp techniques have been mainly used in intracellular recording. A third clamp technique recently receiving attention is the dynamic clamp; this technique enables a real-time interaction between a real neuron and a mathematical model. Here, we review our studies with the dynamic clamp techniques. First, we introduce the dynamic clamp that we recently developed. Next, we show an example of constructing a hybrid network of a real hippocampal CA1 pyramidal neuron and a model interneuron. Finally, we describe perturbation experiments for measuring the phase response curve performed on a real hippocampal CA1 pyramidal neuron. The dynamic clamp enables us to apply theoretical approaches to physiological experiments.
Original language | English |
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Publication status | Published - 2009 Jan 1 |
Event | Asia Simulation Conference 2009, JSST 2009 - Shiga, Japan Duration: 2009 Oct 7 → 2009 Oct 9 |
Other
Other | Asia Simulation Conference 2009, JSST 2009 |
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Country/Territory | Japan |
City | Shiga |
Period | 09/10/7 → 09/10/9 |
Keywords
- Dynamic clamp
- Hybrid network
- Phase response curve
- Rat hippocampal CA1 pyramidal neuron
- Real time simulation
ASJC Scopus subject areas
- Modelling and Simulation