Fusion of real neuron and mathematical model by using dynamic clamp technique

Toru Aonishi, Takamasa Tsunoda, Keisuke Ota, Toshiaki Omori, Masato Okada, Hiroyoshi Miyakawa

Research output: Contribution to conferencePaperpeer-review

Abstract

The current clamp and voltage clamp techniques have been mainly used in intracellular recording. A third clamp technique recently receiving attention is the dynamic clamp; this technique enables a real-time interaction between a real neuron and a mathematical model. Here, we review our studies with the dynamic clamp techniques. First, we introduce the dynamic clamp that we recently developed. Next, we show an example of constructing a hybrid network of a real hippocampal CA1 pyramidal neuron and a model interneuron. Finally, we describe perturbation experiments for measuring the phase response curve performed on a real hippocampal CA1 pyramidal neuron. The dynamic clamp enables us to apply theoretical approaches to physiological experiments.

Original languageEnglish
Publication statusPublished - 2009 Jan 1
EventAsia Simulation Conference 2009, JSST 2009 - Shiga, Japan
Duration: 2009 Oct 72009 Oct 9

Other

OtherAsia Simulation Conference 2009, JSST 2009
CountryJapan
CityShiga
Period09/10/709/10/9

Keywords

  • Dynamic clamp
  • Hybrid network
  • Phase response curve
  • Rat hippocampal CA1 pyramidal neuron
  • Real time simulation

ASJC Scopus subject areas

  • Modelling and Simulation

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