Duplex DNA is bound by a 'two-handed' fullerene (see picture) which allows it to be expressed in mammalian cells. The molecular design relies on the synergy of the hydrophobic fullerene core and the two spatially separated cationic residues. Upon complexation with the fullerene the plasmid (containing a green fluorescent protein reporter gene) is taken up by cultured cells through phagocytosis and expressed in up to 15% of these cells.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2000 Dec 4|
- DNA recognition
- Supramolecular chemistry
ASJC Scopus subject areas