Functionalization of magnetic gold/iron-oxide composite nanoparticles with oligonucleotides and magnetic separation of specific target

Takuya Kinoshita, Satoshi Seino, Yoshiteru Mizukoshi, Takashi Nakagawa, Takao A. Yamamoto

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Magnetic composite nanoparticles of gold and iron-oxide synthesized with gamma-rays or ultrasonics were functionalized with thiol-modified oligonucleotides. The amount of oligonucleotides bound to the functionalized nanoparticle probes via hybridization was quantified with fluorescently-labeled target oligonucleotides. Our composite nanoparticles magnetically separated the specific target oligonucleotides without the non-specific adsorption.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Volume311
Issue number1 SPEC. ISS.
DOIs
Publication statusPublished - 2007 Apr

Keywords

  • Composite nanoparticle
  • Gold
  • Iron-oxide
  • Magnetic separation
  • Oligonucleotide

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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