Functionalization and Magnetic Relaxation of Ferrite Nanoparticles for Theranostics

Daiki Shigeoka, Takahiro Yamazaki, Tomoya Ishikawa, Kazunari Miike, Koki Fujiwara, Taisei Ide, Akito Oshima, Tatsuya Hashimoto, Daiki Aihara, Kouhei Kanda, Akihito Usui, Yoshiyuki Hosokai, Haruo Saito, Yuko Ichiyanagi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Magnetic nanoparticles have drawn attention recently due to their interesting nanoscopic features and potential applications. Various kinds of ferrite nanoparticles with diameters between 3 and 34 nm encapsulated by amorphous SiO2 were functionalized and examined for biomedical applications. From dc and ac magnetic susceptibility measurements, it was found that these particles followed the Néel relaxation system. Co-Zn ferrite (Co0.8Zn0.2Fe2O4) nanoparticles were prepared and the increase in temperature in the ac field was estimated for hyperthermia treatment. In vitro experiments using cultured human breast cancer cells were carried out, and a dramatic hyperthermia effect was observed. As one of the diagnostic methods, magnetic resonance (MR) measurements were performed for CoFe2O4 nanoparticles, and the samples were also evaluated as potential contrast media for MR imaging.

Original languageEnglish
Article number8411164
JournalIEEE Transactions on Magnetics
Issue number11
Publication statusPublished - 2018


  • Magnetic particles
  • magnetic susceptibility
  • medical diagnostic imaging
  • nanoparticles

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering


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