Functional roles of CREB as a positive regulator in the formation and enhancement of memory

Satoshi Kida, Tatsurou Serita

Research output: Contribution to journalReview articlepeer-review

90 Citations (Scopus)

Abstract

cAMP response element-binding (CREB) has been known to be an essential transcription factor that activates gene expression required for the formation of long-term memory (LTM) in a wide range of animal models, from nematodes to higher animals such as Aplysia, Drosophila, and rodents. In mammals, various CREB mutant mice have been developed and analyzed. These studies have shown that gain or loss of CREB function improves and impairs, respectively, the formation of LTMs, enabling us to understand the roles of CREB in the formation and enhancement of memory. In this article, the analyses conducted on CREB mutant mice are reviewed with a particular focus on learning and memory formation. This article is part of a Special Issue entitled 'Memory enhancement'.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalBrain Research Bulletin
Volume105
DOIs
Publication statusPublished - 2014 Jun

Keywords

  • CREB
  • Consolidation
  • Extinction
  • Memory
  • Memory enhancement
  • Reconsolidation

ASJC Scopus subject areas

  • Neuroscience(all)

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