TY - JOUR
T1 - Functional neuroimaging of normal aging
T2 - Declining brain, adapting brain
AU - Sugiura, Motoaki
N1 - Funding Information:
I thank Rui Nouchi for informative suggestions. Preparation of this manuscript is in part supported by Topic-Setting Program to Advance Cutting-Edge Humanities and Social Sciences Research (Area Cultivation) and KAKENHI 25560347 from JSPS.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Early functional neuroimaging research on normal aging brain has been dominated by the interest in cognitive decline. In this framework the age-related compensatory recruitment of prefrontal cortex, in terms of executive system or reduced lateralization, has been established. Further details on these compensatory mechanisms and the findings reflecting cognitive decline, however, remain the matter of intensive investigations. Studies in another framework where age-related neural alteration is considered adaptation to the environmental change are recently burgeoning and appear largely categorized into three domains. The age-related increase in activation of the sensorimotor network may reflect the alteration of the peripheral sensorimotor systems. The increased susceptibility of the network for the mental-state inference to the socioemotional significance may be explained by the age-related motivational shift due to the altered social perception. The age-related change in activation of the self-referential network may be relevant to the focused positive self-concept of elderly driven by a similar motivational shift. Across the domains, the concept of the self and internal model may provide the theoretical bases of this adaptation framework. These two frameworks complement each other to provide a comprehensive view of the normal aging brain.
AB - Early functional neuroimaging research on normal aging brain has been dominated by the interest in cognitive decline. In this framework the age-related compensatory recruitment of prefrontal cortex, in terms of executive system or reduced lateralization, has been established. Further details on these compensatory mechanisms and the findings reflecting cognitive decline, however, remain the matter of intensive investigations. Studies in another framework where age-related neural alteration is considered adaptation to the environmental change are recently burgeoning and appear largely categorized into three domains. The age-related increase in activation of the sensorimotor network may reflect the alteration of the peripheral sensorimotor systems. The increased susceptibility of the network for the mental-state inference to the socioemotional significance may be explained by the age-related motivational shift due to the altered social perception. The age-related change in activation of the self-referential network may be relevant to the focused positive self-concept of elderly driven by a similar motivational shift. Across the domains, the concept of the self and internal model may provide the theoretical bases of this adaptation framework. These two frameworks complement each other to provide a comprehensive view of the normal aging brain.
KW - Adaptation
KW - Aging
KW - Cognitive decline
KW - Functional neuroimaging
KW - fMRI
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U2 - 10.1016/j.arr.2016.02.006
DO - 10.1016/j.arr.2016.02.006
M3 - Review article
C2 - 26988858
AN - SCOPUS:84962171178
VL - 30
SP - 61
EP - 72
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
ER -