Functional MRI mapping of brain activation during visually guided saccades and antisaccades: Cortical and subcortical networks

Tetsuya Matsuda, Masato Matsuura, Tatsunobu Ohkubo, Hiromi Ohkubo, Eisuke Matsushima, Kentaro Inoue, Masato Taira, Takuya Kojima

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)

Abstract

Antisaccade tasks require a subject to inhibit a saccade toward a briefly appearing peripheral target and instead to immediately generate a saccade to an equivalent point in the opposite hemifield. Using functional magnetic resonance imaging (fMRI), we investigated the neural networks required to inhibit reflexive saccades and to voluntarily generate saccades. The results demonstrated that saccade and antisaccade tasks often bilaterally activate frontal, parietal and supplementary eye fields, lenticular nuclei and occipital cortex. Additional activation of bilateral dorsolateral prefrontal cortices, supramarginal gyri, anterior cingulate cortices and thalamus was observed during antisaccade tasks. These results indicate that fronto-parietal and fronto-striato-thalamo-cortical circuits are involved in antisaccade tasks. The fronto-parietal circuit is thought to be related to the planning of saccadic eye movements that involve attentional control, while the fronto-striato-thalamo- cortical circuits connect to cortical region as a feedback network. We speculate that the abnormalities in spatial attention and eye movement control observed in schizophrenia stem from dysfunctions in the fronto-parietal and fronto-striato-thalamo-cortical circuits.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume131
Issue number2
DOIs
Publication statusPublished - 2004 Jul 30

Keywords

  • Antisaccade
  • Eye movements
  • Fronto-parietal network
  • Fronto-striato-thalamo-cortical network
  • Functional MRI
  • Saccade

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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