Functional Monomers and Polymers CLXXVII. Synthesis and Interaction Studies of Water Soluble Nucleic Acid Analogs: Polyethyleneimine Derivatives Containing Uracil and 5- Fluorouracil

Takehiko Wada, Yoshiaki Inaki, Kiichi Takemoto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Nucleic acid analogs were prepared by grafting uracil and 5-fluorouracil de rivatives containing a hydroxy group onto linear polyethyleneimine. The polymers contained about 90 unit% of the nucleic acid bases, and were freely soluble in water at neutral pH value. They were found to form polymer com plexes with polynucleotide by specific base-base interaction in aqueous solu tion.

Original languageEnglish
Pages (from-to)25-41
Number of pages17
JournalJournal of Bioactive and Compatible Polymers
Volume4
Issue number1
DOIs
Publication statusPublished - 1989 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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