Functional monomers and polymers clxxi. Synthesis and interaction studies on water soluble nucleic acid analogs: Polyethyleneimine derivatives containing cytosine and hypoxanthine

Nucleic acid analogs were prepared by grafting cytosine and hypoxanthine derivatives containing hydroxyl groups onto linear polyethyleneimine. The polymers contained about 90 unit mol% of the nucleic acid bases, and were easily soluble in water at neutral pH value. They were found to form polymer complexes with polynucleotides (PolyI and PolyC) by specific base-base interactions in aqueous solution.