Functional localization of kinesin/microtubule-based motility system along metallic glass microwires

K. Kim, A. Sikora, K. S. Nakayama, H. Nakazawa, M. Umetsu, W. Hwang, W. Teizer

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We report an approach using metallic glass microwires for functional organization of kinesin/microtubule-based molecular motility systems along a quasi-one-dimensional track. The molecular motility system assembled along a metallic glass microwire exhibits the typical kinesin-powered gliding motion of microtubules, while the variance of the gliding direction depends on the wire diameter. As a result of the geometrical boundary condition given by the wire tracks, the angle within which the orientations of gliding microtubules fall becomes narrower for smaller wire diameter. Such behavior supports the feasibility of using microwires as a simple and flexible means of spatial regulation of the molecule-based in-vitro motion. Furthermore, the metallic glass wires interact with microtubules, the negatively charged polyelectrolyte, by creating electric fields. We experimentally demonstrate how the electric field-induced forces act as an additional control parameter in the wire-based manipulation of the molecular motility system.

Original languageEnglish
Article number143701
JournalApplied Physics Letters
Volume105
Issue number14
DOIs
Publication statusPublished - 2014 Oct 6

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Fingerprint Dive into the research topics of 'Functional localization of kinesin/microtubule-based motility system along metallic glass microwires'. Together they form a unique fingerprint.

Cite this